Endocrine Abstracts

TSH-secreting pituitary adenoma (thyrotropinoma) is a rare (0.5% of all pituitary adenomas) and usually benign pituitary lesion, arising from the monoclonal expansion of neoplastic thyrotrophes. Thyrotropinoma usually presents with symptoms thyrotoxicosis (milder compared to those originating from the primary thyroid disorders) and mass effects of the pituitary tumour.Aim: To describe the clinical course of thyrotropinoma presented with paroxysmal atrial...

Introduction: The important aspect of vitamin D (vitD) sufficiency is the impact of chronic diseases and medications, which disturb the metabolism of vitD. Bone pathology is common in diseases of the endocrine system, so the determining the status of vitD in various endocrine diseases and comparing it to otherwise healthy controls is of particular interest.Materials and methods: The study included 16 patients with type 2 diabetes mellitus (T2DM), 23 pati...

Introduction: Numerous literature sources indicate the potential role of hyperprolactinemia in the development of obesity. Prolactin modulates the functional activity of several enzymes and transporters in adipose tissue and islets of Langerhans, potentially influencing fat and glucose metabolism. On the other hand, elevated prolactin level may induce eating disorders due to dysfunction of dopaminergic regulation of the CNS. We present a clinical case of a man with morbid obes...

Introduction: The silent corticotropinomas (SC) account for 1.1–6% of surgically removed pituitary adenomas and 17–22% of ACTH-immunoreactive tumours. They do not cause prominent clinical features of hypercortisolism, nor biochemically evident, but show positive immunostaining for ACTH similar to functional corticotropinomas, They usually present as non-functioning adenomas (NFPA) with local mass effects and/or visual impairment.Aim: To describ...

Introduction: Copeptin is a proposed new diagnostic marker in differential diagnosis of diabetes insipidus as it is secreted in equimolar concentrations with vasopressin. Thus our aim was to assess diagnostic value of copeptin evaluation in patients with polydipsic-polyuric disorders.Materials and Methods: We’ve evaluated the copeptin (BRAHMS CT-proAVP Kryptor), sodium levels and blood/urine osmolality in 26 healthy volunteers (1M/25F, mean age 24.7...

Introduction: Extremely low levels of vitamin D usually include levels < 4 ng/ml, which is almost the same as undetectable. The risk groups for vitamin D deficiency have been identified, but do they allow such patients to be identified based solely on clinical presentation.Objective: To identify risk factors and their actual clinical determination in patients with 25(OH)D serum levels <4 ng/ml.Materials and methods: The stu...

Prolactinomas are the most common hormone-active pituitary tumors, most common in young women, whose main reason for going to the doctor is menstrual irregularity. At the onset of the disease before puberty in children, there is a delay in sexual development, in girls primary amenorrhea.A 27-year old woman has been observed since 15 years, when hyperprolactinemia was first detected, level of PRL was 10 900 IU/l, and according to MRI pituitary endose...

Experience in complex therapy of selective and non-selective dopamine agonists in women with resistant prolactinomas for recovering of ovulation function.Introduction: Prolactinomas are the most common pituitary adenomas and dopamine agonists (DA) still remain the first choice of treatment. Nevertheless, it does not always exert an adequate effect and endocrinologists face the challenge of resistant prolactinomas more frequently. This problem is very imp...

Silent corticotropinomas (SCAs) are a subtype of non-functioning pituitary adenomas (NFPAs) demonstrating positive immunoreactivity for ACTH, but without clinical or biochemical features of hypercortisolism. SCAs typically present as macroadenomas with symptoms related to a local mass effect. In some cases SCAs can transform into hormonal active formations with gradually developing symptoms of hypercortisolism.The aim: To describe a patient with NFPA who...

Introduction: Hyponatriemia is one of severe postoperative water-electrolyte disturbances. This condition is usually caused by syndrome of inappropriate secretion of antidiuretic hormone or cerebral salt-wasting syndrome which require different treatment approaches.Case presentation: A 61-year-old woman was referred to tertiary care center with non-functioning pituitary macroadenoma. The patient had been suffering from headaches for 4 later years and had...